Overview

Our lab’s research focuses on experimental and computational approaches to understanding the neural correlates of consciousness in humans—specifically how sleep affects the brain. We specialize in using the state-of-the-art in quantitative approaches to develop novel statistical signal processing algorithms for the analysis of neural data, with direct applications to basic science, biomarker discovery, and medical device development.

Selected Publications

Stokes PA,  Rath P, Possidente P, He M, Purcell A, Manoach SA, Stickgold E, Prerau MJ, Transient Oscillation Dynamics During Sleep Provide a Robust Basis for Electroencephalographic Phenotyping and Biomarker Identification, Sleep, 2022;, zsac223, doi: 10.1093/sleep/zsac223

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Chen S, Redline S, Eden UT, Prerau MJ, Dynamic Models of Obstructive Sleep Apnea Provide Robust Prediction of Respiratory Event Timing and a Statistical Framework for Phenotype Exploration, Sleep, 2022;, zsac189, doi: 10.1093/sleep/zsac189

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Dimitrov T, He M, Stickgold R, Prerau MJ, Sleep spindles comprise a subset of a broader class of electroencephalogram events, Sleep, 2021;, zsab099, https://doi.org/10.1093/sleep/zsab099

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Stokes PA, Prerau MJ. Estimation of Time-Varying Spectral Peaks and Decomposition of EEG Spectrograms. IEEE Access. 2020;8:218257-218278. doi: 10.1109/access.2020.3042737. Epub 2020 Dec 4. PMID: 33816040; PMCID: PMC8015841.
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Djonlagic I, Mariani S, Fitzpatrick AL, Van Der Klei VMGTH, Johnson DA, Wood AC, Seeman T, Nguyen HT, Prerau MJ, Luchsinger JA, Dzierzewski JM, Rapp SR, Tranah GJ, Yaffe K, Burdick KE, Stone KL, Redline S, Purcell SM. Macro and micro sleep architecture and cognitive performance in older adults. Nat Hum Behav. 2020 Nov 16;. doi: 10.1038/s41562-020-00964-y. PubMed PMID: 33199858.

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Smagula SF, Sofer T, Guo N, Prerau MJ, Purcell S, Mariani S, Yaffe K, Redline S, Stone KL. Spectral sleep electroencephalographic correlates of sleep efficiency, and discrepancies between actigraphy and self-reported measures, in older men. J Sleep Res. 2020 Mar 21;:e13033. doi: 10.1111/jsr.13033. PubMed PMID: 32198950; PubMed Central PMCID: PMC7607534.

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Thomas RJ, Chen S, Eden UT, Prerau MJ. Quantifying statistical uncertainty in metrics of sleep disordered breathing. Sleep Medicine, Volume 65, 2020, Pages 161-169, ISSN 1389-9457, doi: 10.1016/j.sleep.2019.06.003.
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AHI Tools
Song AH, Chlon L, Soulat H, Tauber J, Subramanian S, Ba D, Prerau MJ. Multitaper Infinite Hidden Markov Model for EEG. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:5803-5807. doi: 10.1109/EMBC.2019.8856817. PubMed PMID: 31947171; PubMed Central PMCID: PMC7029542.

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Prerau MJ, Bianchi MT, Brown RE, Ellenbogen JM, Patrick PL. Sleep Neurophysiological Dynamics Through the Lens of Multitaper Spectral Analysis. Physiology (Bethesda). 2017 Jan;32(1):60-92. Review. doi: 10.1152/physiol.00062.2015 PubMed PMID: 27927806.

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Prerau MJ, Hartnack KE, Obregon-Henao G, Sampson A, Merlino M, Gannon K, Bianchi MT, Ellenbogen JM, Purdon PL. Tracking the Sleep Onset Process: An Empirical Model of Behavioral and Physiological Dynamics. Diedrichsen J, editor. PLoS Comput. Biol. Public Library of Science; 2014 Oct;10(10):e1003866. doi: 10.1371/journal.pcbi.1003866 PMCID: PMC4183428.

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Prerau MJ, Lipton PA, Eichenbaum HB, Eden UT. Characterizing context-dependent differential firing activity in the hippocampus and entorhinal cortex. Hippocampus. 2014 Apr;24(4):476–92. doi: 10.1002/hipo.22243 PMCID: PMC3966990.

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Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KFK, Salazar-Gomez AF, Harrell PG, Sampson AL, Cimenser A, Ching S, Kopell NJ, Tavares-Stoeckel C, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci USA. National Acad Sciences; 2013 Mar 19;110(12):E1142–51. doi: 10.1073/pnas.1221180110 PMCID: PMC3607036.

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Prerau MJ, Eden UT. A general likelihood framework for characterizing the time course of neural activity. Neural Comput 2011; 23 (10): 2537–2566. doi: 10.1162/NECO_a_00185

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Prerau MJ, Smith AC, Eden UT, Kubota Y, Yanike M, Suzuki W, Graybiel AM, Brown EN. Characterizing learning by simultaneous analysis of continuous and binary measures of performance. J Neurophysiol. 2009 Nov;102(5):3060–72. doi: 10.1152/jn.91251.2008 PMCID: PMC2777819.

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Prerau MJ, Smith AC, Eden UT, Yanike M, Suzuki WA, Brown EN. A mixed filter algorithm for cognitive state estimation from simultaneously recorded continuous and binary measures of performance. Biol Cybern. 2008 Jul;99(1):1–14. doi: 10.1007/s00422-008-0227-z PMCID: PMC2707852.

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